TBC1D1 Antibodies

AND TBC1D1 ELISA kits, TBC1D1 Proteins

Many biological assays use antibodies to detect TBC1D1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBC1D1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBC1D1 antibodies...

We validate the specificity of these antibodies to TBC1D1 by testing them on tissues known to express TBC1D1 positively and negatively. Browse below to find the TBC1D1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TBC1D1 Infographic by Boster Bio

All TBC1D1 Products

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Product

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Specificity

Applications

Price

TBC1D1 TBC1 Domain Family, Member 1 Human Recombinant Protein

Human

$250
Cat # PROTQ86TI0
5ug, 20ug, 1mg

Anti-TBC1 domain family member 1 TBC1D1 Antibody

Human

ELISA, WB

$449
Cat # A03667
0.1 mg

TBC1D1 (NM_015173) Human Over-expression Lysate

Human

$628
Cat # LS023216
100 µg

TBC1D1 Overview

Facts about TBC1 domain family member 1.

TBC1D1 3D structure. Source: alphafold

TBC1 domain family member 1 (TBC1D1)

May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues.

Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). .

Gene Information

Human
Gene Name:	TBC1D1
Uniprot:	Q86TI0
Entrez:	23216

Family

Belongs to:

No superfamily

Alternative Names

KIAA1108TBC; TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; TBC1 domain family member 1; TBC1

Molecular Weight

Mass (kDA):
133.084 kDA

Genomic Context


Human

Location:	4p14
Sequence:	4; NC_000004.12 (37891084..38139175)

Subcellular Localizations

Nucleus.

Diseases

Obesity
Insulin Resistance
Insulin Sensitivity
Diabetes Mellitus, Non-insulin-dependent
Diabetes Mellitus
Hyperinsulinism
Metabolic Syndrome X
Neoplasms
Hyperglycemia
Overnutrition
Sclerosis

Stomach Neoplasms
Dyslipidemias
Primary Lateral Sclerosis
Thymoma
Hypoxia
Endometrial Polyp

Interacting Proteins

APPL2

Pathways

Transport
Glucose Transport
Muscle Contraction
Cell Cycle
Cell Differentiation
Regulation Of Glucose Transport
Cell Growth
Pathogenesis
Glucose Homeostasis
Phagocytosis
Translation
Estrus
Regulation Of Gtpase Activity

Cell Development
Mitosis
Insemination
Localization
Lipid Oxidation
Mast Cell Differentiation
Skeletal Muscle Contraction

PTMs

Phosphorylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBC1D1

References

PMID: 24879834 by Cheng K.K., et al. The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.

PMID: 21454505 by Park S.Y., et al. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase- activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.