Synaptotagmin-7 (SYT7)

Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to constructed SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).

SYT7 binds Ca(2+) with high affinity and slow kinetics in comparison to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594).