SOSTDC1 Antibodies

AND SOSTDC1 ELISA kits, SOSTDC1 Proteins

Many biological assays use antibodies to detect SOSTDC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SOSTDC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SOSTDC1 antibodies...

We validate the specificity of these antibodies to SOSTDC1 by testing them on tissues known to express SOSTDC1 positively and negatively. Browse below to find the SOSTDC1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SOSTDC1 Infographic by Boster Bio

All SOSTDC1 Products

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Product

Figures

Specificity

Applications

Price

Human USAG1 Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ6X4U4
Starting from 20ug

SOSTDC1 (NM_015464) Human Over-expression Lysate

Human

$628
Cat # LS025928
100 µg

SOSTDC1 Overview

Facts about Sclerostin domain-containing protein 1.

SOSTDC1 3D structure. Source: alphafold

Sclerostin domain-containing protein 1 (SOSTDC1)

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 at a dose-dependent manner.

Gene Information

Human
Gene Name:	SOSTDC1
Uniprot:	Q6X4U4
Entrez:	25928

Family

Belongs to:

sclerostin family

Alternative Names

CDA019; cystine-knot containing secreted protein; DKFZp564D206; Ectodermal BMP inhibitor; Ectodin; sclerostin domain containing 1; sclerostin domain-containing protein 1; SOSTDC1; USAG1; USAG-1; USAG1uterine sensitization-associated protein-1; Uterine sensitization-associated gene 1 protein; WISE

Molecular Weight

Mass (kDA):
23.307 kDA

Genomic Context


Human

Location:	7p21.2
Sequence:	7; NC_000007.14 (16461481..16465738, complement)

Tissue Specificity

Highly expressed in kidney and weakly in lung.

Subcellular Localizations

Secreted.

Diseases

Kidney Diseases
Malignant Neoplasms
Injury To Kidney
Neoplasms
Tooth, Supernumerary
Kidney Failure, Chronic
Kidney Neoplasm
Cell Transformation, Neoplastic
Carcinoma
Fibrosis
Renal Cell Carcinoma
Diabetes Mellitus
Nephroblastoma

Malignant Neoplasm Of Kidney
Malignant Neoplasm Of Stomach
Limb Deformities, Congenital
Diabetic Nephropathy
Limb Defect
Malignant Neoplasm Of Breast
Malignant Tumor Of Colon

Pathways

Localization
Hair Follicle Development
Sensitization
Secretion
Cell Adhesion
Cell Migration
Programmed Cell Death
Aging
Lung Development
Cell Fate Determination
Glucose Homeostasis
Cell Cycle
Paracrine Signaling

Cell Communication
Embryonic Morphogenesis
Lung Morphogenesis
Appendage Development
Cell Proliferation
Gastrulation
Pancreas Development

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOSTDC1

References

PMID: 14623234 by Laurikkala J., et al. Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.

PMID: 15020244 by Yanagita M., et al. USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.