STXBP1 Antibodies

AND STXBP1 ELISA kits, STXBP1 Proteins

Many biological assays use antibodies to detect STXBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STXBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STXBP1 antibodies...

We validate the specificity of these antibodies to STXBP1 by testing them on tissues known to express STXBP1 positively and negatively. Browse below to find the STXBP1 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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STXBP1 Infographic by Boster Bio

All STXBP1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Munc18-1/STXBP1 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB9819
100 μg/vial

Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody

3 Q&As

Mouse, Rat

IHC, WB

$481
Cat # P02351
100 µl

Anti-Phospho-Unc18-1 (S313) STXBP1 Antibody

Human, Monkey, Mouse, Rat

ELISA, WB

$380
Cat # A02351S313
100ul

Munc18 1 (STXBP1) (NM_003165) Human Recombinant Protein

$1249
Cat # PROTP61764
20 µg

Anti-STXBP1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M02351
100 μl/vial

Munc18 1 (STXBP1) (NM_003165) Human Over-expression Lysate

Human

$628
Cat # LS006812
100 µg

STXBP1 Overview

Facts about Syntaxin-binding protein 1.

STXBP1 3D structure. Source: alphafold

Syntaxin-binding protein 1 (STXBP1)

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio.

Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Gene Information

Human
Gene Name:	STXBP1
Uniprot:	P61764
Entrez:	6812

Family

Belongs to:

STXBP/unc-18/SEC1 family

Alternative Names

EIEE4; FLJ37475; hUNC18; MUNC18-1; NSEC1; N-Sec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; STXBP1; syntaxin binding protein 1; syntaxin-binding protein 1; SyntaxinBP1; Syntaxin-BP1; UNC18; unc18-1; UNC18A; unc-18A; UNC18neuronal SEC1

Molecular Weight

Mass (kDA):
67.569 kDA

Genomic Context


Human

Location:	9q34.11
Sequence:	9; NC_000009.12 (127611912..127696029)

Tissue Specificity

Brain and spinal cord. Highly enriched in axons.

Subcellular Localizations

Cytoplasm, cytosol. Membrane; Peripheral membrane protein.

Diseases

Epilepsy
Encephalopathies
Early Infantile Epileptic Encephalopathy With Burst-suppression
Infantile Spasms
Haploinsufficiency
Spasm
Nervousness
Diabetes Mellitus
Epilepsies, Myoclonic
Retinopathy Of Prematurity
Partial Seizure

Alzheimer's Disease
Infantile Severe Myoclonic Epilepsy
Neoplasms
Pituitary Diseases
Impaired Cognition
Nerve Degeneration

Interacting Proteins

C19orf57
HSPA8
MEOX2
PSEN1
STX11

STX19
STX5
TRIM38

Pathways

Exocytosis
Secretion
Membrane Fusion
Vesicle Docking
Transport
Localization
Vesicle Fusion
Pathogenesis
Synaptic Vesicle Exocytosis
Insulin Secretion
Neurotransmitter Secretion
Vesicle Transport
Synaptic Transmission

Cell Differentiation
Secretory Pathway
Aging
Snare Complex Assembly
Synaptic Vesicle Fusion
Synaptic Vesicle Priming
Spermatogenesis

PTMs

Phosphorylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STXBP1

References

PMID: 8824310 by Gengyo-Ando K., et al. A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.

PMID: 9545644 by Swanson D.A., et al. Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release.