Serine palmitoyltransferase small subunit A (Sptssa)

Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference.

The SPTLC1-SPTLC2- SPTSSA complex indicates a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme utilizes both C14-CoA and C16- CoA as substrates, with a small preference for C14-CoA (By similarity). .