SPTLC1 Antibodies

AND SPTLC1 ELISA kits, SPTLC1 Proteins

Many biological assays use antibodies to detect SPTLC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPTLC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPTLC1 antibodies...

We validate the specificity of these antibodies to SPTLC1 by testing them on tissues known to express SPTLC1 positively and negatively. Browse below to find the SPTLC1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPTLC1 Infographic by Boster Bio

All SPTLC1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-SPTLC1 Antibody Picoband®

1 Q&As

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB9894
100 μg/vial

Anti-Serine palmitoyltransferase 1 SPTLC1 Antibody Picoband®

7 Q&As

Human

IHC, WB

$370
Cat # PA1777
100 μg/vial

Anti-Serine palmitoyltransferase 1 SPTLC1 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A03680
100ul

SPTLC1 (NM_006415) Human Over-expression Lysate

Human

$960
Cat # LS010558
100 µg

SPTLC1 Overview

Facts about Serine palmitoyltransferase 1.

SPTLC1 3D structure. Source: alphafold

Serine palmitoyltransferase 1 (SPTLC1)

Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 represents the catalytic core.

The composition of this serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex indicates a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme utilizes both C14-CoA and C16-CoA as substrates, with a small preference for C14-CoA.

Gene Information

Human
Gene Name:	SPTLC1
Uniprot:	O15269
Entrez:	10558

Family

Belongs to:

class-II pyridoxal-phosphate-dependent aminotransferase family

Alternative Names

EC 2.3.1.50; hereditary sensory neuropathy, type 1; HSAN1; LBC1; LCB 1; LCB1HSAN; Long chain base biosynthesis protein 1; MGC14645; serine C-palmitoyltransferase; serine palmitoyltransferase 1; serine palmitoyltransferase, long chain base subunit 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1HSN1; SPTI

Molecular Weight

Mass (kDA):
52.744 kDA

Genomic Context


Human

Location:	9q22.31
Sequence:	9; NC_000009.12 (92031141..92115413, complement)

Tissue Specificity

Widely expressed. Not detected in small intestine.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Hereditary Sensory And Autonomic Neuropathies
Sensory Neuropathy
Sensory Neuropathy, Hereditary
Hereditary Sensory Autonomic Neuropathy, Type 1
Absence Of Sensation
Peripheral Neuropathy
Pain
Ulcer
Weakness
Nervousness
Inherited Neuropathy

Atherosclerosis
Charcot-marie-tooth Disease
Arthropathy
Infective Disorder
Nerve Degeneration
Abnormal Degeneration

Interacting Proteins

ORMDL3
SPTLC3

Pathways

Localization
Pathogenesis
Transport
Cell Migration
Cell Proliferation
Cell Death
Neural Tube Closure
Glycosylation
Hypersensitivity
Reflex
Tube Closure

Gastric Emptying
Chemotaxis
Cholesterol Efflux
Cell Growth
Intestinal Cholesterol Absorption
Cholesterol Homeostasis

PTMs

Cleavage

Glycosylation

Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPTLC1

References

PMID: 9363775 by Weiss B., et al. Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis.

PMID: 11242114 by Dawkins J.L., et al. Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I.