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Vinexin Antibodies
AND SORBS3 ELISA kits, Vinexin Proteins
Many biological assays use antibodies to detect Vinexin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Vinexin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Vinexin antibodies...
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SORBS3 Infographic by Boster Bio
All SORBS3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05794
100 μg/vial
Cat # A05794
100 μg/vial
SORBS3 Overview
Facts about Vinexin.
Vinexin (SORBS3)
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
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Gene Information
| Human | |
|---|---|
| Gene Name: | SORBS3 |
| Uniprot: | O60504 |
| Entrez: | 10174 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
SCAM-1SH3-containing adapter molecule 1; SCAM1vinexin beta (SH3-containing adaptor molecule-1); SH3D4VINEXIN; sorbin and SH3 domain containing 3; Sorbin and SH3 domain-containing protein 3; vinexin
Molecular Weight
Mass (kDA):
75.341 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (22544990..22575788) |
Tissue Specificity
Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
Subcellular Localizations
[Isoform Alpha]: Cell junction. Cytoplasm, cytoskeleton. Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites.; [Isoform Beta]: Cell junction. Nucleus. Cytoplasm, cytoskeleton. Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus.
Diseases
- Tissue Adhesions
- Carcinoma
- Malignant Squamous Cell Neoplasm
- Cell Transformation, Neoplastic
- Liver Carcinoma
- Malignant Neoplasm Of Breast
- Hepatitis
- Hepatitis B
- Virus Diseases
- Malignant Neoplasms
Interacting Proteins
- ABL1
- CPNE2
- HNRNPK
- HNRNPUL1
- INPPL1
- KIAA0408
- NCKIPSD
- PAK2
- PAK5
- RARG
Pathways
- Cell Adhesion
- Keratinocyte Migration
- Cell Migration
- Cell Proliferation
- Wound Healing
- Localization
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SORBS3
bosterbio.com/bosterbio-gene-info-cards/SORBS3
References
PMID: 9885244 by Kioka N., et al. Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization.
PMID: 10585480 by Akamatsu M., et al. Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities.