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Zinc finger protein SNAI1 Antibodies
AND SNAI1 ELISA kits, Zinc finger protein SNAI1 Proteins
Many biological assays use antibodies to detect Zinc finger protein SNAI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein SNAI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein SNAI1 antibodies...
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SNAI1 Infographic by Boster Bio
All SNAI1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1532
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1532
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2339
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2339
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00716-2
100 μg/vial
Cat # A00716-2
100 μg/vial
SNAI1 Overview
Facts about Zinc finger protein SNAI1.
Zinc finger protein SNAI1 (SNAI1)
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 amounts and represses transcription.
Throughout EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 into pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SNAI1 |
| Uniprot: | O95863 |
| Entrez: | 6615 |
Family
| Belongs to: |
|---|
| snail C2H2-type zinc-finger protein family |
Alternative Names
Protein sna; Protein snail homolog 1; SLUGH2; SNA; SNAH; SNAHdJ710H13.1; SNAI1; snail 1 (drosophila homolog), zinc finger protein; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail homolog 1 (Drosophila); Snail; zinc finger protein SNAI1
Molecular Weight
Mass (kDA):
29.083 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.13 |
| Sequence: | 20; NC_000020.11 (49982980..49988886) |
Tissue Specificity
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
Subcellular Localizations
Nucleus. Cytoplasm. Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Cell Invasion
- Carcinoma
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Mammary Neoplasms
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Fibrosis
Interacting Proteins
- ACTN2
- AJUBA
- BTRC
- CREBBP
- Crebbp
- EP300
- FBXL14
- FBXO11
- GSK3B
- HDAC1
Pathways
- Epithelial To Mesenchymal Transition
- Cell Migration
- Cell Differentiation
- Wound Healing
- Cell Adhesion
- Cell Motility
- Pathogenesis
- Gastrulation
- Cell-cell Adhesion
- Cell Proliferation
- Cell Cycle
- Localization
- Methylation
PTMs
- Phosphorylation
- Methylation
- Demethylation
Research Areas
- Breast Cancer
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNAI1
bosterbio.com/bosterbio-gene-info-cards/SNAI1
References
PMID: 11245431 by Okubo T., et al. Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH).
PMID: 10543399 by Twigg S.R., et al. Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis.