SIGLEC7 Antibodies

AND SIGLEC7 ELISA kits, SIGLEC7 Proteins

Many biological assays use antibodies to detect SIGLEC7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIGLEC7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIGLEC7 antibodies...

We validate the specificity of these antibodies to SIGLEC7 by testing them on tissues known to express SIGLEC7 positively and negatively. Browse below to find the SIGLEC7 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: TRMT2A

SIGLEC7 Infographic by Boster Bio

All SIGLEC7 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human Siglec-7/CD328 ELISA Kit PicoKine®

7 Q&As

Human

ELISA

$499
Cat # EK1508
96 wells/kit, with removable strips.

Anti-CD328 SIGLEC7 Antibody

7 Q&As

Human

IHC, WB

$399
Cat # A06553
100μl

Human Siglec-7/CD328 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9Y286
Starting from 10ug

Anti-Siglec 7 (SIGLEC7) Mouse Monoclonal Antibody [Clone ID: OTI1A1]

Human

$523
Cat # M06553
100 µl

Siglec 7 (SIGLEC7) (NM_014385) Human Over-expression Lysate

Human

$628
Cat # LS027036
100 µg

SIGLEC7 Overview

Facts about Sialic acid-binding Ig-like lectin 7.

SIGLEC7 3D structure. Source: alphafold

Sialic acid-binding Ig-like lectin 7 (SIGLEC7)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid.

Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Information

Human
Gene Name:	SIGLEC7
Uniprot:	Q9Y286
Entrez:	27036

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

Adhesion inhibitory receptor molecule 1; adhesion inhibitory receptor molecule 1, siglec-7; AIRM1; AIRM-1; AIRM1QA79 membrane protein; CD328 antigen; CD328; CDw328; D-siglec; p75; p75/AIRM1; QA79; sialic acid binding Ig-like lectin 7; sialic acid binding immunoglobulin-like lectin 7; sialic acid-binding Ig-like lectin 7; Siglec7; Siglec-7

Molecular Weight

Mass (kDA):
51.143 kDA

Genomic Context


Human

Location:	19q13.41
Sequence:	19; NC_000019.10 (51142260..51153526)

Tissue Specificity

Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Neoplasm Metastasis
Kidney Neoplasm
Carcinoma
Neoplasms
Renal Cell Carcinoma
Leukemia
Tumor Progression
Colonic Neoplasms
Basophilic Leukemia
Chimera Disorder
Hepatitis

Embolism
Malignant Paraganglionic Neoplasm
Hepatitis C
Tissue Adhesions
Impairment (finding)
Viremia

Pathways

Glycosylation
Cell Activation
Cell-cell Recognition
Methylation
Histone Deacetylation
Host-pathogen Interaction
Cell Death
Dna Methylation
Endocytosis

Viral Replication
Localization
Secretion

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIGLEC7

References

PMID: 10567377 by Nicoll G., et al. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes.

PMID: 10499918 by Falco M., et al. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.