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SERPINA5 Antibodies
AND SERPINA5 ELISA kits, SERPINA5 Proteins
Many biological assays use antibodies to detect SERPINA5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SERPINA5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SERPINA5 antibodies...
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SERPINA5 Infographic by Boster Bio
All SERPINA5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # A01916-1
100 μg/vial
Cat # A01916-1
100 μg/vial
Human
ELISA
$499
Cat # EK1631
96 wells/kit, with removable strips.
Cat # EK1631
96 wells/kit, with removable strips.
Dog, Human, Mouse
WB
$523
Cat # M01916-1
100 µl
Cat # M01916-1
100 µl
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M01916
100 µl
Cat # M01916
100 µl
SERPINA5 Overview
Facts about Plasma serine protease inhibitor.
Plasma serine protease inhibitor (SERPINA5)
Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation website.
Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic functions in the blood plasma.
Gene Information
| Human | |
|---|---|
| Gene Name: | SERPINA5 |
| Uniprot: | P05154 |
| Entrez: | 5104 |
Family
| Belongs to: |
|---|
| serpin family |
Alternative Names
Acrosomal serine protease inhibitor; antitrypsin), member 5; member 5; PAI-3; PAI3PLANH3; PCI; PCIplasminogen activator inhibitor III; Plasminogen activator inhibitor 3; plasminogen activator inhibitor-3; PROCIplasma serine protease inhibitor; Protein C inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase; Serpin A5; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin); SERPNA5
Molecular Weight
Mass (kDA):
45.675 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.13 |
| Sequence: | 14; NC_000014.9 (94581426..94593118) |
Tissue Specificity
Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate.
Subcellular Localizations
Secreted, extracellular space. Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
Diseases
- Neoplasms
- Arteriopathic Disease
- Inflammation
- Peritoneal Neoplasms
- Neoplasm Metastasis
- Atresia
- Ataxia
- Pulmonary Embolism
- Carcinoma
- Peripheral Vascular Diseases
- Malignant Neoplasms
- Cerebrovascular Accident
Pathways
- Coagulation
- Sertoli Cell Development
- Cell Development
- Fertilization
- Localization
- Cell Maturation
- Regeneration
- Tissue Regeneration
- Growth Hormone Secretion
- Fibrinolysis
PTMs
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPINA5
bosterbio.com/bosterbio-gene-info-cards/SERPINA5
References
PMID: 3027058 by Suzuki K., et al. Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.
PMID: 2173165 by Meijers J.C.M., et al. Evidence for a glycine residue at position 316 in human protein C inhibitor.