Septin-4 Antibodies

AND SEPTIN4 ELISA kits, Septin-4 Proteins

Many biological assays use antibodies to detect Septin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Septin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Septin-4 antibodies...

We validate the specificity of these antibodies to Septin-4 by testing them on tissues known to express SEPTIN4 positively and negatively. Browse below to find the SEPTIN4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SEPTIN4 Infographic by Boster Bio

All SEPTIN4 Products

Product

Figures

Specificity

Applications

Price

Anti-SEPT4/SEPTIN4 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A09411-2
100 μg/vial

SEPTIN4 (NM_004574) Human Over-expression Lysate

Human

$960
Cat # LS005414
100 µg

SEPTIN4 Overview

Facts about Septin-4.

SEPTIN4 3D structure. Source: alphafold

Septin-4 (SEPTIN4)

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Forms a filamentous arrangement with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus that's needed for the structural integrity and motility of the sperm tail through postmeiotic differentiation (PubMed:25588830). May play a role in platelet secretion.

Gene Information

Human
Gene Name:	SEPTIN4
Uniprot:	O43236
Entrez:	5414

Family

Belongs to:

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily

Alternative Names

Septin-4

Molecular Weight

Mass (kDA):
55.098 kDA

Genomic Context


Human

Location:	17q22
Sequence:	17; NC_000017.11 (58520250..58544372, complement)

Tissue Specificity

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. In platelets, found in areas surrounding alpha-granules. Found in the sperm annulus (PubMed:25588830).; [Isoform ARTS]: Mitochondrion. Nucleus. While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.

Interacting Proteins

SIAH1
XIAP

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEPTIN4

References

PMID: 9889007 by Paavola P., et al. Characterization of a novel gene, PNUTL2, on human chromosome 17q22- q23 and its exclusion as the Meckel syndrome gene.

PMID: 11167005 by Zieger B., et al. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2.