This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Septin-4.
Forms a filamentous arrangement with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus that's needed for the structural integrity and motility of the sperm tail through postmeiotic differentiation (PubMed:25588830). May play a role in platelet secretion.
Human | |
---|---|
Gene Name: | SEPTIN4 |
Uniprot: | O43236 |
Entrez: | 5414 |
Belongs to: |
---|
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily |
Septin-4
Mass (kDA):
55.098 kDA
Human | |
---|---|
Location: | 17q22 |
Sequence: | 17; NC_000017.11 (58520250..58544372, complement) |
Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. In platelets, found in areas surrounding alpha-granules. Found in the sperm annulus (PubMed:25588830).; [Isoform ARTS]: Mitochondrion. Nucleus. While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.
PMID: 9889007 by Paavola P., et al. Characterization of a novel gene, PNUTL2, on human chromosome 17q22- q23 and its exclusion as the Meckel syndrome gene.
PMID: 11167005 by Zieger B., et al. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2.