Semaphorin-3E (SEMA3E)

Plays an important role in signaling through the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections.

Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Can down- regulate sprouting angiogenesis.