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Podoplanin Antibodies
AND PDPN ELISA kits, Podoplanin Proteins
Many biological assays use antibodies to detect Podoplanin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Podoplanin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Podoplanin antibodies...
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PDPN Infographic by Boster Bio
All PDPN Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, IF, IHC
$486
Cat # M01124
100ug/vial
Cat # M01124
100ug/vial
Anti-Podoplanin/gp36/Pdpn Antibody Picoband®
2 Citations
Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01124-2
100 μg/vial
Cat # A01124-2
100 μg/vial
Human
Flow Cytometry, IHC, WB
$523
Cat # M01124-3
100 µl
Cat # M01124-3
100 µl
PDPN Overview
Facts about Podoplanin.
Podoplanin (PDPN)
During evolution plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721).
Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and activating RHOA activation leading to cell migration growth and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267).
Gene Information
| Human | |
|---|---|
| Gene Name: | PDPN |
| Uniprot: | Q86YL7 |
| Entrez: | 10630 |
Family
| Belongs to: |
|---|
| podoplanin family |
Alternative Names
36-KD; Aggrus; Gp36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); OTS 8; OTS8; PA2.26 antigen; PDPN; Podoplanin; RANDAM-2; T1A; T1A-2; T1-alpha
Molecular Weight
Mass (kDA):
16.698 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.21 |
| Sequence: | 1; NC_000001.11 (13583757..13617957) |
Tissue Specificity
Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
Subcellular Localizations
[Podoplanin]: Membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Membrane raft. Apical cell membrane. Basolateral cell membrane. Cell projection, invadopodium. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles (By similarity). Association to t
Diseases
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Lymphatic Metastasis
- Cell Invasion
- Metastatic Malignant Neoplasm To The Lymph Node
- Malignant Squamous Cell Neoplasm
- Malignant Paraganglionic Neoplasm
- Neoplasm Invasiveness
- Lung Neoplasms
- Adenocarcinoma
- Sarcoma
Pathways
- Lymphangiogenesis
- Platelet Aggregation
- Cell Migration
- Localization
- Cell Proliferation
- Angiogenesis
- Pathogenesis
- Platelet Activation
- Cell Motility
- Tube Formation
- Wound Healing
- Cell Growth
- Cell Adhesion
PTMs
- Phosphorylation
- Glycosylation
Research Areas
- Core ESC-Like Genes
- Signal Transduction
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDPN
bosterbio.com/bosterbio-gene-info-cards/PDPN
References
PMID: 9651190 by Ma T., et al. Evidence against a role of mouse, rat, and two cloned human T1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.
PMID: 10393083 by Zimmer G., et al. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium.
2 Publications of Boster Podoplanin Antibodies & ELISA Kits
- PubMed ID: 10.1002/ijc.26035, Lymphatic endothelial cell‐secreted CXCL1 stimulates lymphangiogenesis and met...
- PubMed ID: 32417325, Wang F,Ji S,Wang M,Liu L,Li Q,Jiang F,Cen J,Ji B.HMGB1 promoted P-glycoprotein a...
*More publications can be found for each product on its corresponding product page