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PTGDS Antibodies
AND PTGDS ELISA kits, PTGDS Proteins
Many biological assays use antibodies to detect PTGDS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTGDS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTGDS antibodies...
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PTGDS Infographic by Boster Bio
All PTGDS Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS005730
100 µg
Cat # LS005730
100 µg
PTGDS Overview
Facts about Prostaglandin-H2 D-isomerase.
Prostaglandin-H2 D-isomerase (PTGDS)
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a powerful inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic part in oligodendrocytes.
Binds little non-substrate lipophilic molecules, such as biliverdin, bilirubin, retinal, retinoic acid and thyroid gland, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous comedy and blood-testis barrier.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTGDS |
| Uniprot: | P41222 |
| Entrez: | 5730 |
Family
| Belongs to: |
|---|
| calycin superfamily |
Alternative Names
Beta-trace protein; Cerebrin-28; EC 5.3.99.2; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; L-PGDS; PDS; PGD2 Synthase; PGD2; PGDS2; PGDSLPGDS; PH2DISO; prostaglandin D synthase; prostaglandin D2 synthase (21kD, brain); prostaglandin D2 synthase 21kDa (brain); Prostaglandin-D2 synthase; prostaglandin-H2 D-isomerase; PTGDS
Molecular Weight
Mass (kDA):
21.029 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.3 |
| Sequence: | 9; NC_000009.12 (136977504..136981742) |
Tissue Specificity
Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes.
Subcellular Localizations
Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the pe
Diseases
- Malignant Neoplasms
- Schizophrenia
- Congenital Abnormality
- Mental Disorders
- Bipolar Disorder
- Infertility
- Neoplasms
- Flushing
- Sclerosis
- Psychiatric Diagnosis
- Mood Disorders
- Cell Transformation, Neoplastic
Interacting Proteins
- KRTAP10-7
- UBQLN2
Pathways
- Cell Migration
- Sex Determination
- Pathogenesis
- Cell Differentiation
- Gonad Development
- Cell Death
- Secretion
- Transport
- Cell Adhesion
- Sertoli Cell Development
- Hibernation
- Sertoli Cell Differentiation
- Cell Activation
PTMs
- Disulfide bond
Research Areas
- Mast Cell Markers
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTGDS
bosterbio.com/bosterbio-gene-info-cards/PTGDS
References
PMID: 1902577 by Nagata A., et al. Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins.
PMID: 1385416 by White D.M., et al. Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase.