26S proteasome regulatory subunit 4 (PSMC1)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays an integral role in the maintenance of protein homeostasis by eliminating misfolded or damaged proteins, which could impair cellular functions, and by eliminating proteins whose functions are no longer required.

Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 is owned by the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins which unfolds ubiquitinated target proteins which are simultaneously translocated into a proteolytic room and degraded into peptides.