PRIMA1 Antibodies

AND PRIMA1 ELISA kits, PRIMA1 Proteins

Many biological assays use antibodies to detect PRIMA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRIMA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRIMA1 antibodies...

We validate the specificity of these antibodies to PRIMA1 by testing them on tissues known to express PRIMA1 positively and negatively. Browse below to find the PRIMA1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRIMA1 Infographic by Boster Bio

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Proline rich membrane anchor 1 (PRIMA1) (NM_178013) Human Over-expression Lysate

Human

$628
Cat # LS145270
100 µg

PRIMA1 Overview

Facts about Proline-rich membrane anchor 1.

PRIMA1 3D structure. Source: alphafold

Proline-rich membrane anchor 1 (PRIMA1)

Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in mind. Also able to organize ACHE into tetramers (By similarity).

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Gene Information

Human
Gene Name:	PRIMA1
Uniprot:	Q86XR5
Entrez:	145270

Family

Belongs to:

No superfamily

Alternative Names

Protein Phosphatase 1 Regulatory Subunit 3E; Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3E; Protein Phosphatase 1, Regulatory Subunit 3E

Molecular Weight

Mass (kDA):
16.689 kDA

Genomic Context


Human

Location:	14q32.12
Sequence:	14; NC_000014.9 (93718298..93789029, complement)

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, synapse. In the brain, PRIMA linked to ACHE is found in membrane rafts.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Chronic Lymphocytic Leukemia
Cell Transformation, Neoplastic
Leukemia
Lymphoid Leukemia
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Colonic Neoplasms
Malignant Tumor Of Colon
Sleep Disorders

Neoplasm Invasiveness
Malignant Neoplasm Of Lung
Endoplasmic Reticulum Stress
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Nervousness
Mammary Neoplasms

Pathways

Localization
Methylation
Dna Methylation
Innervation
Secretion
Bioluminescence
Secretory Pathway
Brain Development
Glycosylation
Neuron Differentiation

Cell Cycle Arrest
Drug Resistance
Cell Death
Cell Cycle

PTMs

Cleavage
Methylation

Phosphorylation
Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRIMA1

References

PMID: 11804574 by Perrier A.L., et al. PRiMA: the membrane anchor of acetylcholinesterase in the brain.

PMID: 19368807 by Xie H.Q., et al. Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation.