PNPLA6 Antibodies

AND PNPLA6 ELISA kits, PNPLA6 Proteins

Many biological assays use antibodies to detect PNPLA6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PNPLA6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PNPLA6 antibodies...

We validate the specificity of these antibodies to PNPLA6 by testing them on tissues known to express PNPLA6 positively and negatively. Browse below to find the PNPLA6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PNPLA6 Infographic by Boster Bio

All PNPLA6 Products

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Specificity

Applications

Price

Anti-NTE PNPLA6 Antibody

13 Q&As

Human, Mouse, Rat

IHC, WB

$399
Cat # A04071
100μl

Anti-PNPLA6 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A04071-2
100 µg/vial

PNPLA6 Overview

Facts about Neuropathy target esterase.

PNPLA6 3D structure. Source: alphafold

Neuropathy target esterase (PNPLA6)

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho.

Its particular chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. .

Gene Information

Human
Gene Name:	PNPLA6
Uniprot:	Q8IY17
Entrez:	10908

Family

Belongs to:

NTE family

Alternative Names

EC 3.1.1.5; neuropathy target esterase; NTENTEMND; patatin-like phospholipase domain containing 6; Patatin-like phospholipase domain-containing protein 6; SPG39; sws

Molecular Weight

Mass (kDA):
150.954 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (7534164..7561767)

Tissue Specificity

Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side. Anchored to the cytoplasmic face of the endoplasmic reticulum by its N-terminal transmembrane segment.

Pathways

Cell Differentiation

PTMs

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PNPLA6

References

PMID: 9576844 by Lush M.J., et al. Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man.

PMID: 1666291 by Lotti M.; The pathogenesis of organophosphate polyneuropathy.