PLEKHH2 Antibodies

AND PLEKHH2 ELISA kits, PLEKHH2 Proteins

Many biological assays use antibodies to detect PLEKHH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLEKHH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLEKHH2 antibodies...

We validate the specificity of these antibodies to PLEKHH2 by testing them on tissues known to express PLEKHH2 positively and negatively. Browse below to find the PLEKHH2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLEKHH2 Infographic by Boster Bio

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PLEKHH2 (NM_172069) Human Over-expression Lysate

Human

$960
Cat # LS130271
100 µg

PLEKHH2 Overview

Facts about Pleckstrin homology domain-containing family H member 2.

PLEKHH2 3D structure. Source: alphafold

Pleckstrin homology domain-containing family H member 2 (PLEKHH2)

In the kidney glomerulus can play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization.

Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. .

Gene Information

Human
Gene Name:	PLEKHH2
Uniprot:	Q8IVE3
Entrez:	130271

Family

Belongs to:

No superfamily

Alternative Names

KIAA2028; pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; PLEKHH1L

Molecular Weight

Mass (kDA):
168.229 kDA

Genomic Context


Human

Location:	2p21
Sequence:	2; NC_000002.12 (43637260..43767987)

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K.

Diseases

Kidney Diseases
Segmental Glomerulosclerosis
Diabetic Nephropathy
Proteinuria Of Undiagnosed Cause
Focal Glomerulosclerosis
Nephrosis
Complications Of Diabetes Mellitus
Tissue Adhesions

Glomerulosclerosis (disorder)
Diabetes Mellitus
Dysequilibrium Syndrome

Interacting Proteins

LPXN

Pathways

Localization

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEKHH2

References

PMID: 22832517 by Perisic L., et al. Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics.