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- Table of Contents
Facts about Pejvakin.
Mouse | |
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Gene Name: | Pjvk |
Uniprot: | Q0ZLH2 |
Entrez: | 381375 |
Belongs to: |
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gasdermin family |
Pejvakin
Mass (kDA):
39.858 kDA
Mouse | |
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Location: | 2|2 C3 |
Sequence: | 2; |
In ear, it is detected in the organ of Corti and the spiral ganglion within the cochlea in the sensory areas of the vestibule (cristae ampullares of the semicircular ducts, and maculae of the saccule and utricle) and in the first 3 relays (cochlear nuclei, superior olivary complex and inferior colliculus) of the afferent auditory pathway. In the afferent auditory pathway, it is present in the cell bodies of neurons but not in fiber bundles such as the trapezoid body in the brainstem. Also detected in spiral ganglion cells, which form the auditory nerve and project to the cochlear nuclei in the brainstem. Also present in the cochlear nuclei, the superior olive and the inferior colliculus (at protein level). Expressed in all the adult organs tested: brain, eye, inner ear, heart, lung, kidney, liver, intestine, testis and weakly in skeletal muscle.
PMID: 16804542 by Delmaghani S., et al. Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy.