PASD1 Antibodies

AND PASD1 ELISA kits, PASD1 Proteins

Many biological assays use antibodies to detect PASD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PASD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PASD1 antibodies...

We validate the specificity of these antibodies to PASD1 by testing them on tissues known to express PASD1 positively and negatively. Browse below to find the PASD1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PASD1 Infographic by Boster Bio

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PASD1 (NM_173493) Human Over-expression Lysate

Human

$628
Cat # LS139135
100 µg

PASD1 Overview

Facts about Circadian clock protein PASD1.

PASD1 3D structure. Source: alphafold

Circadian clock protein PASD1 (PASD1)

Acts as a suppressor of the biological clock which drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock parts (PubMed:25936801).

Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801). .

Gene Information

Human
Gene Name:	PASD1
Uniprot:	Q8IV76
Entrez:	139135

Family

Belongs to:

No superfamily

Alternative Names

CT63Cancer/testis antigen 63; OXTES1; OX-TES-1; PAS domain containing 1; PAS domain-containing protein 1

Molecular Weight

Mass (kDA):
87.428 kDA

Genomic Context


Human

Location:	Xq28
Sequence:	X; NC_000023.11 (151563184..151676739)

Tissue Specificity

Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL- derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).

Subcellular Localizations

[Isoform 1]: Nucleus. Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).; [Isoform 2]: Nucleus. Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).

Diseases

Malignant Neoplasms
Lymphoma
Neoplasms
B-cell Lymphomas
Diffuse Large B-cell Lymphoma
Adenoma
Carcinoma
Multiple Myeloma
Adenocarcinoma
Hematologic Neoplasms
Testicular Neoplasms
Lung Neoplasms
Lung Adenoma

Adenocarcinoma Of Lung (disorder)
Basal Cell Carcinoma
Neoplasm Metastasis
Tetanus
Hematopoietic Neoplasms
Myeloid Leukemia, Chronic
Carcinogenesis

Pathways

Immune Response

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PASD1

References

PMID: 15162151 by Liggins A.P., et al. A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein.

PMID: 16112646 by Guinn B.-A., et al. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.