OSTC Antibodies

AND OSTC ELISA kits, OSTC Proteins

Many biological assays use antibodies to detect OSTC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OSTC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OSTC antibodies...

We validate the specificity of these antibodies to OSTC by testing them on tissues known to express OSTC positively and negatively. Browse below to find the OSTC antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OSTC Infographic by Boster Bio

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OSTC (NM_021227) Human Over-expression Lysate

Human

$628
Cat # LS058505
100 µg

OSTC Overview

Facts about Oligosaccharyltransferase complex subunit OSTC.

OSTC 3D structure. Source: alphafold

Oligosaccharyltransferase complex subunit OSTC (OSTC)

May act as substrate-specific component of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. May be involved in N-glycosylation of APP (amyloid-beta precursor protein).

Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. .

Gene Information

Human
Gene Name:	OSTC
Uniprot:	Q9NRP0
Entrez:	58505

Family

Belongs to:

OSTC family

Alternative Names

DC2; Hydrophobic protein HSF-28; oligosaccharyltransferase complex subunit OSTC; oligosaccharyltransferase complex subunit

Molecular Weight

Mass (kDA):
16.829 kDA

Genomic Context


Human

Location:	4q25
Sequence:	4; NC_000004.12 (108650585..108667822)

Subcellular Localizations

Endoplasmic reticulum. Membrane; Multi-pass membrane protein.

Diseases

Osteoporosis, Postmenopausal
Osteoporosis

Interacting Proteins

Pathways

Glycosylation

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OSTC

References

PMID: 15146197 by Brandenberger R., et al. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

PMID: 21768116 by Wilson C.M., et al. DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma- secretase-directed processing of amyloid precursor protein (APP).