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Homeobox protein Nkx-2.1 Antibodies
AND NKX2-1 ELISA kits, Homeobox protein Nkx-2.1 Proteins
Many biological assays use antibodies to detect Homeobox protein Nkx-2.1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Homeobox protein Nkx-2.1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Homeobox protein Nkx-2.1 antibodies...
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NKX2-1 Infographic by Boster Bio
All NKX2-1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC
$486
Cat # M01322
100ug/vial
Cat # M01322
100ug/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01322-1
100 μl
Cat # M01322-1
100 μl
Human
IHC, WB
$431
Cat # M01322-2
100uL
Cat # M01322-2
100uL
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$449
Cat # A01322
0.1 mg
Cat # A01322
0.1 mg
NKX2-1 Overview
Facts about Homeobox protein Nkx-2.1.
Homeobox protein Nkx-2.1 (NKX2-1)
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the upkeep of the thyroid differentiation phenotype.
May play a role in lung development and surfactant homeostasis. Types a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | NKX2-1 |
| Uniprot: | P43699 |
| Entrez: | 7080 |
Family
| Belongs to: |
|---|
| NK-2 homeobox family |
Alternative Names
BCH; benign chorea; BHC; Homeobox protein NK-2 homolog A; homeobox protein Nkx-2.1; NK2 homeobox 1; NK-2 homolog A; NKX2.1; NKX2-1; NKX2A; NKX2ANKX2.1; T/EBP; Thyroid nuclear factor 1; Thyroid transcription factor 1BHC; TITF1; TITF1TEBP; TTF1; TTF-1; TTF1BCH; TTF-1NK-2
Molecular Weight
Mass (kDA):
38.596 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q13.3 |
| Sequence: | 14; NC_000014.9 (36516397..36520232, complement) |
Tissue Specificity
Thyroid and lung.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Adenocarcinoma
- Hypothyroidism
- Congenital Hypothyroidism
- Carcinoma
- Adenocarcinoma Of Lung (disorder)
- Lung Diseases
- Haploinsufficiency
- Chorea
- Thyroid Neoplasm
Interacting Proteins
- CCDC59
- NCK1
Pathways
- Lung Development
- Cell Proliferation
- Dna Methylation
- Methylation
- Cell Migration
- Cell Cycle
- Lung Morphogenesis
- Organ Development
- Atp-dependent Chromatin Remodeling
- Dna Hypermethylation
- Brain Development
- Aging
- Histone Modification
PTMs
- Methylation
- Phosphorylation
Research Areas
- Membrane Trafficking and Chaperones
- Tumor Biomarkers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NKX2-1
bosterbio.com/bosterbio-gene-info-cards/NKX2-1
References
PMID: 7711079 by Oguchi H., et al. The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein.
PMID: 7711080 by Saiardi A., et al. Cloning and sequence analysis of human thyroid transcription factor 1.