NHS Antibodies

AND NHS ELISA kits, NHS Proteins

Many biological assays use antibodies to detect NHS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NHS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NHS antibodies...

We validate the specificity of these antibodies to NHS by testing them on tissues known to express NHS positively and negatively. Browse below to find the NHS antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NHS Infographic by Boster Bio

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NHS Overview

Facts about Nance-Horan syndrome protein.

NHS 3D structure. Source: alphafold

Nance-Horan syndrome protein (NHS)

May function in cell morphology by keeping the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, mind and craniofacial development.

Gene Information

Human
Gene Name:	NHS
Uniprot:	Q6T4R5
Entrez:	4810

Family

Belongs to:

NHS family

Alternative Names

Congenital cataracts and dental anomalies protein; CXN; DKFZp781F2016; DKFZp781L0254; FLJ22511; Nance-Horan syndrome (congenital cataracts and dental anomalies); Nance-Horan syndrome protein; SCML1

Molecular Weight

Mass (kDA):
179.135 kDA

Genomic Context


Human

Location:	Xp22.2-p22.13
Sequence:	X; NC_000023.11 (17375200..17735994)

Tissue Specificity

Detected at low levels in all tissues analyzed. Detected in fetal and adult brain, lens, retina, retinal pigment epithelium, placenta, lymphocytes and fibroblasts. Levels in retinal pigment epithelium, placenta, lymphocytes, and fibroblasts are very low. Expressed also in kidney, lung and thymus.

Subcellular Localizations

[Isoform 1]: Apical cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, tight junction. Cell junction, focal adhesion. Colocalizes with the tight junction protein TJP1 in epithelial cells. Localizes to the leading edge of lamellipodia in motile cells.; [Isoform 3]: Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Pain
Mammary Neoplasms
Mental Disorders
Diabetes Mellitus
Malignant Neoplasm Of Breast
Infective Disorder
Anxiety Disorders
Depressive Disorder
Heart Diseases
Cerebrovascular Accident
Obesity

Ulcer
Cardiovascular Diseases
Cross Infection
Coronary Heart Disease
Hiv Infections
Hemorrhage
Myocardial Infarction

Pathways

Complement Activation
Conjugation
Transport
Pathogenesis
Aging
Secretion
Regeneration
Phagocytosis
Menopause
Localization
Opsonization
Wound Healing
Translation

Immune Response
Cell Proliferation
Menarche
Cell Growth
Excretion
Inflammatory Response
Cognition

PTMs

Cleavage
Biotinylation
Carboxylation
Reduction
Oxidation
Acylation
Phosphorylation
Glycosylation
Amination

Deacetylation
Amidation
Iodination
Acetylation
Methylation
Phosphorothioation
Nitration
Gamma-carboxylation
Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NHS

References

PMID: 14564667 by Burdon K.P., et al. Mutations in a novel gene, NHS, cause the pleiotropic effects of Nance-Horan syndrome, including severe congenital cataract, dental anomalies, and mental retardation.

PMID: 16675532 by Sharma S., et al. Nance-Horan syndrome protein, NHS, associates with epithelial cell junctions.