NDST1 Antibodies

AND NDST1 ELISA kits, NDST1 Proteins

Many biological assays use antibodies to detect NDST1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NDST1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NDST1 antibodies...

We validate the specificity of these antibodies to NDST1 by testing them on tissues known to express NDST1 positively and negatively. Browse below to find the NDST1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NDST1 Infographic by Boster Bio

All NDST1 Products

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Product

Figures

Specificity

Applications

Price

Anti-NDST1 Antibody

Human

ELISA, WB

$449
Cat # A05596
0.1 mg

NDST1 (NM_001543) Human Recombinant Protein

$1249
Cat # PROTP52848
20 µg

NDST1 (NM_001543) Human Over-expression Lysate

Human

$960
Cat # LS003340
100 µg

NDST1 Overview

Facts about Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1.

NDST1 3D structure. Source: alphafold

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (NDST1)

Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar back to produce N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:10758005, PubMed:12634318).

Plays a role in determining the scope and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required.

Gene Information

Human
Gene Name:	NDST1
Uniprot:	P52848
Entrez:	3340

Family

Belongs to:

sulfotransferase 1 family

Alternative Names

[Heparan sulfate]-glucosamine N-sulfotransferase 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; EC 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; HSNST 1; HSNST1; HSST1; HSSTN-HSST 1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; NDST1; NDST-1; N-heparan sulfate sulfotransferase 1; NST1

Molecular Weight

Mass (kDA):
100.868 kDA

Genomic Context


Human

Location:	5q33.1
Sequence:	5; NC_000005.10 (150497779..150558211)

Tissue Specificity

Widely expressed. Expression is most abundant in heart, liver and pancreas.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Inflammation
Neoplasm Metastasis
Carcinoma
Dysplasia
Tumor Angiogenesis
Malignant Neoplasms
Neoplasms
Pathologic Neovascularization
Hypoplasia
Vascular System Injuries
Tissue Adhesions
Leukemia

Cholangiocarcinoma
Stomach Neoplasms
Mutation Abnormality
Metastatic Malignant Neoplasm To The Lymph Node
Neoplasms, Experimental
Fetal Growth Retardation
Gastric Adenocarcinoma

Pathways

Sulfation
Cell Proliferation
Lacrimal Gland Development
Cell Differentiation
Gland Development
Muscle Cell Proliferation
Cell Migration
Chemotaxis
Smooth Muscle Cell Proliferation
Cell Growth
Angiogenesis
Transport
Stem Cell Differentiation

Regulation Of Vasculogenesis
Immune Response
Lung Development
Osteoblast Proliferation
Tube Fusion
Cell Fate Determination
Ossification

PTMs

Phosphorylation
Deacetylation

Reduction
Glycosylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDST1

References

PMID: 7601448 by Dixon J., et al. Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32- q33.1.

PMID: 9230113 by Humphries D.E., et al. Localization of human heparan glucosaminyl N-deacetylase/N- sulphotransferase to the trans-Golgi network.