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MSR1 Antibodies
AND MSR1 ELISA kits, MSR1 Proteins
Many biological assays use antibodies to detect MSR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MSR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MSR1 antibodies...
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MSR1 Infographic by Boster Bio
All MSR1 Products
Product
Figures
Specificity
Applications
Price
$1249
Cat # PROTP21757
20 µg
Cat # PROTP21757
20 µg
Human
IHC, WB
$523
Cat # M02349
100 µl
Cat # M02349
100 µl
Human
$628
Cat # LS004481
100 µg
Cat # LS004481
100 µg
MSR1 Overview
Facts about Macrophage scavenger receptor types I and II.
Macrophage scavenger receptor types I and II (MSR1)
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist.
These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586).
Gene Information
| Human | |
|---|---|
| Gene Name: | MSR1 |
| Uniprot: | P21757 |
| Entrez: | 4481 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD204 antigen; CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; MSR1; phSR1; phSR2; SCARA1; SCARA1macrophage scavenger receptor types I and II; Scavenger receptor class A member 1; scavenger receptor class A, member 1; SR-A; SRAI; SR-AI
Molecular Weight
Mass (kDA):
49.762 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p22 |
| Sequence: | 8; NC_000008.11 (16107878..16192791, complement) |
Tissue Specificity
Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain.
Subcellular Localizations
Membrane; Single-pass type II membrane protein.
Diseases
- Malignant Neoplasms
- Atherosclerosis
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Neoplasms
- Tissue Adhesions
- Arteriosclerosis
- Inflammation
- Dental Plaque
- Alzheimer's Disease
- Fibrosis
- Adenocarcinoma
Interacting Proteins
- ATP6V0C
- HOOK3
- MALL
- NKG7
- SEC22A
Pathways
- Endocytosis
- Pathogenesis
- Phagocytosis
- Secretion
- Cell Adhesion
- Immune Response
- Inflammatory Response
- Cell Death
- Localization
- Macrophage Activation
- Macrophage Differentiation
- Apoptotic Cell Clearance
- Cholesterol Esterification
PTMs
- Acetylation
- Phosphorylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MSR1
bosterbio.com/bosterbio-gene-info-cards/MSR1
References
PMID: 2251254 by Matsumoto A., et al. Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.
PMID: 9548586 by Gough P.J., et al. A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake.