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- Table of Contents
Facts about Male-specific lethal 1 homolog.
Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at'Lys-35' (H2BK34Ub). This modification then stimulates histone H3 methylation at'Lys-5' (H3K4me) and'Lys-80' (H3K79me) and leads to gene activation, such as that of HOXA9 and MEIS1.
Mouse | |
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Gene Name: | Msl1 |
Uniprot: | Q6PDM1 |
Entrez: | 74026 |
Belongs to: |
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msl-1 family |
Male-specific lethal 1 homolog
Mass (kDA):
67.32 kDA
Mouse | |
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Location: | 11|11 D |
Sequence: | 11; |
Expressed in testis and several other tissues.
PMID: 16119455 by Dmitriev R.I., et al. Tissue specificity of alternative splicing products of mouse mRNA encoding new protein hampin homologous to the Drosophila MSL-1 protein.
PMID: 17335777 by Dmitriev R.I., et al. Characterization of hampin/MSL1 as a node in the nuclear interactome.