Male-specific lethal 1 homolog (Msl1)

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at'Lys-17' that is implicated in the creation of higher-order chromatin. Construction (By similarity).

Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at'Lys-35' (H2BK34Ub). This modification then stimulates histone H3 methylation at'Lys-5' (H3K4me) and'Lys-80' (H3K79me) and leads to gene activation, such as that of HOXA9 and MEIS1.