DNA mismatch repair protein Msh6 (MSH6)

Component of the post-replicative DNA mismatch repair system (MMR). When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and admits single base mismatches and dinucleotide insertion-deletion loops (IDL) from the DNA.

Following mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR occasions, such as strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.