MPIG6B Antibodies

AND MPIG6B ELISA kits, MPIG6B Proteins

Many biological assays use antibodies to detect MPIG6B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MPIG6B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MPIG6B antibodies...

We validate the specificity of these antibodies to MPIG6B by testing them on tissues known to express MPIG6B positively and negatively. Browse below to find the MPIG6B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: PRR3

MPIG6B Infographic by Boster Bio

All MPIG6B Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

MPIG6B (NM_138274) Human Over-expression Lysate

Human

$628
Cat # LS080739
100 µg

MPIG6B Overview

Facts about Megakaryocyte and platelet inhibitory receptor G6b.

MPIG6B 3D structure. Source: alphafold

Megakaryocyte and platelet inhibitory receptor G6b (MPIG6B)

Inhibitory receptor that acts as a crucial regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801).

This regulation of megakaryocate function in addition to platelet production ann activation is done through the inhibition (through the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to function in a calcium-independent manner (PubMed:12665801).

Gene Information

Human
Gene Name:	MPIG6B
Uniprot:	O95866
Entrez:	80739

Family

Belongs to:

No superfamily

Alternative Names

C6orf25; chromosome 6 open reading frame 25; G6b; immunoglobulin receptor; MGC142279; MGC142281; NG31; protein G6b

Molecular Weight

Mass (kDA):
26.163 kDA

Genomic Context


Human

Location:	6p21.33
Sequence:	6; NC_000006.12 (31720557..31726710)

Tissue Specificity

Expressed in platelets. Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U- 937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT.

Subcellular Localizations

[Isoform E]: Endoplasmic reticulum. Golgi apparatus.; [Isoform D]: Endoplasmic reticulum. Golgi apparatus.; [Isoform B]: Cell membrane; Single-pass type I membrane protein.; [Isoform A]: Cell membrane; Single-pass type I membrane protein.

Diseases

Autoimmune Reaction
Ankylosing Spondylitis
Autoimmune Diseases
Spondylitis

Pathways

Platelet Activation
Localization
Translation
Immune Response
Wound Healing
Platelet Aggregation

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPIG6B

References

PMID: 11544253 by de Vet E.C.M., et al. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2.

PMID: 15848171 by de Vet E.C., et al. The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin.