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- Table of Contents
Facts about Mapk-regulated corepressor-interacting protein 1.
When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) leading to transcriptional silencing of the E- cadherin gene and induction of epithelial-mesenchymal transition. .
Mouse | |
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Gene Name: | Mcrip1 |
Uniprot: | Q3UGS4 |
Entrez: | 192173 |
Belongs to: |
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MCRIP family |
Mapk-regulated corepressor-interacting protein 1
Mass (kDA):
11.101 kDA
Mouse | |
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Location: | 11|11 E2 |
Sequence: | 11; |
Widely expressed (at protein level).
PMID: 25728771 by Ichikawa K., et al. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.