MAP6 Antibodies

AND MAP6 ELISA kits, MAP6 Proteins

Many biological assays use antibodies to detect MAP6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP6 antibodies...

We validate the specificity of these antibodies to MAP6 by testing them on tissues known to express MAP6 positively and negatively. Browse below to find the MAP6 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAP6 Infographic by Boster Bio

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MAP6 (NM_033063) Human Over-expression Lysate

Human

$960
Cat # LS004135
100 µg

MAP6 Overview

Facts about Microtubule-associated protein 6.

MAP6 3D structure. Source: alphafold

Microtubule-associated protein 6 (MAP6)

Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Especially has microtubule cold stabilizing activity (By similarity).

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking through its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal freight transport (By similarity).

Gene Information

Human
Gene Name:	MAP6
Uniprot:	Q96JE9
Entrez:	4135

Family

Belongs to:

STOP family

Alternative Names

microtubule-associated protein 6

Molecular Weight

Mass (kDA):
86.505 kDA

Genomic Context


Human

Location:	11q13.5
Sequence:	11; NC_000011.10 (75586914..75668724, complement)

Tissue Specificity

Expressed in brain (at protein level). Expressed in spinal cord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study).

Subcellular Localizations

Cytoplasm, cytoskeleton. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of

Diseases

Schizophrenia
Malignant Neoplasms
Malignant Neoplasm Of Prostate
Prostatic Neoplasms
Sclerosis
Local Disease
Primary Lateral Sclerosis
Mood Disorders
Dementia
Breast Adenocarcinoma
Amyotrophic Lateral Sclerosis
Progressive Supranuclear Palsy
Supranuclear Palsy

Neoplasms
Mammary Neoplasms
Lymphoma
Cytogenetic Abnormality
Myotonic Dystrophy
Neurofibrillary Tangles
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Pathways

Short-term Memory
Hibernation
Golgi Localization
Regulation Of Cytoskeleton
Endocytosis
Localization
Rna Splicing
Cell Division
Drug Resistance
Neuroprotection

Synaptic Vesicle Endocytosis
Mrna Splicing
Interphase
Pathogenesis

PTMs

Phosphorylation
Acetylation

Dephosphorylation
Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP6

References

PMID: 14692697 by Letournel F., et al. Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis.

PMID: 16624526 by Shimizu H., et al. Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia.