Lysyl oxidase homolog 3 Antibodies

AND Loxl3 ELISA kits, Lysyl oxidase homolog 3 Proteins

Many biological assays use antibodies to detect Lysyl oxidase homolog 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lysyl oxidase homolog 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lysyl oxidase homolog 3 antibodies...

We validate the specificity of these antibodies to Lysyl oxidase homolog 3 by testing them on tissues known to express Loxl3 positively and negatively. Browse below to find the Loxl3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LOXL3 (NM_032603) Human Over-expression Lysate

Human

$960
Cat # LS084695
100 µg

Loxl3 Overview

Facts about Lysyl oxidase homolog 3.

Lysyl oxidase homolog 3 (Loxl3)

Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:26954549). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of saliva and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:26307084).

Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (PubMed:26954549). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600).

Gene Information

Mouse
Gene Name:	Loxl3
Uniprot:	Q9Z175
Entrez:	16950

Family

Belongs to:

lysyl oxidase family

Alternative Names

EC 1.4.3; EC 1.4.3.-; EC 1.4.3.13; LOL3; LOXL; LOXL3; Lysyl Oxidase Homolog 3; lysyl oxidase-like 3; Lysyl oxidase-like protein 3

Molecular Weight

Mass (kDA):
83.74 kDA

Genomic Context


Mouse

Location:	6 C3\|6 35.94 cM
Sequence:	6;

Tissue Specificity

Expressed in palate: predominantly present in the palate mesenchyme and tongue (at protein level) (PubMed:26307084). In spine, expressed in the original intervertebral disk, cartilage primordia, anterior and posterior longitudinal ligaments, meninges of spinal cord, lung and heart (PubMed:26307084). In eyes, strongly expressed in the skin of the eyelid and weakly expressed in the cornea and sclera (PubMed:26307084). In lung, predominantly expressed in the pulmonary mesenchyme (PubMed:27645581). In developing muscle, expressed at myofiber ends (at protein level) (PubMed:26954549).