LETM1 Antibodies

AND LETM1 ELISA kits, LETM1 Proteins

Many biological assays use antibodies to detect LETM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LETM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LETM1 antibodies...

We validate the specificity of these antibodies to LETM1 by testing them on tissues known to express LETM1 positively and negatively. Browse below to find the LETM1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LETM1 Infographic by Boster Bio

All LETM1 Products

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Product

Figures

Specificity

Applications

Price

Anti-LETM1 Antibody

Human, Mouse, Rat

$405
Cat # A04547
100ul

LETM1 (NM_012318) Human Over-expression Lysate

Human

$628
Cat # LS003954
100 µg

LETM1 Overview

Facts about Mitochondrial proton/calcium exchanger protein.

LETM1 3D structure. Source: alphafold

Mitochondrial proton/calcium exchanger protein (LETM1)

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306).

Required for the maintenance of the tubular form and cristae organization (PubMed:18628306). Compared to SLC8B1/NCLX, doesn't constitute the significant element for mitochondrial calcium extrusion (PubMed:24898248).

Gene Information

Human
Gene Name:	LETM1
Uniprot:	O95202
Entrez:	3954

Family

Belongs to:

LETM1 family

Alternative Names

LETM1 and EF-hand domain-containing protein 1, mitochondrial; leucine zipper-EF-hand containing transmembrane protein 1; Leucine zipper-EF-hand-containing transmembrane protein 1; Mdm38 homolog

Molecular Weight

Mass (kDA):
83.354 kDA

Genomic Context


Human

Location:	4p16.3
Sequence:	4; NC_000004.12 (1811479..1856156, complement)

Subcellular Localizations

Mitochondrion inner membrane; Single-pass membrane protein.

Diseases

Wolf-hirschhorn Syndrome
Edema
Malignant Neoplasms
Neoplasms
Muscle Hypotonia
Haploinsufficiency
Craniofacial Abnormalities
Cell Transformation, Neoplastic
Optic Atrophy
Wolfram Syndrome
Mitochondrial Diseases

Microcephaly
Atrophy
Diabetes Mellitus
Epilepsy
Trisomy

Interacting Proteins

PSMA3

Pathways

Transport
Rna Interference
Translation
Cell Death
Insulin Secretion
Ion Transport
Membrane Fusion
Oxidative Phosphorylation
Protein Transport
Ion Homeostasis
Mitochondrial Fusion
Seed Development
Antiport

Cell Cycle
Necrotic Cell Death
Regulation Of Mitochondrial Translation
Mitochondrial Translation
Cell Growth
Pathogenesis
Secretion

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LETM1

References

PMID: 10486213 by Endele S., et al. LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients.

PMID: 14706454 by Schlickum S., et al. LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein.