Kcnk18 Antibodies

AND Kcnk18 ELISA kits, Kcnk18 Proteins

Many biological assays use antibodies to detect Kcnk18, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kcnk18 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kcnk18 antibodies...

We validate the specificity of these antibodies to Kcnk18 by testing them on tissues known to express Kcnk18 positively and negatively. Browse below to find the Kcnk18 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Kcnk18 Infographic by Boster Bio

All Kcnk18 Products

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Product

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Specificity

Applications

Price

Anti-TRESK KCNK18 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A07164
0.1 mg

KCNK18 (NM_181840) Human Over-expression Lysate

Human

$628
Cat # LS338567
100 µg

Kcnk18 Overview

Facts about Potassium channel subfamily K member 18.

Potassium channel subfamily K member 18 (Kcnk18)

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents.

May function as background potassium channel which sets the resting membrane potential. Channel activity is directly activated by calcium signal.

Gene Information

Mouse
Gene Name:	Kcnk18
Uniprot:	Q6VV64
Entrez:	332396

Family

Belongs to:

two pore domain potassium channel (TC 1.A.1.8) family

Alternative Names

K2p18.1; potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; TRESK2; TRESK-2; TRESKTWIK-related spinal cord potassium channel; TRIKMGR13; TWIK-related individual K+ channel; TWIK-related individual potassium channel; TWIK-related spinal cord K+ channel

Molecular Weight

Mass (kDA):
44.403 kDA

Genomic Context


Mouse

Location:	19\|19 D3
Sequence:	19;

Tissue Specificity

Detected in brain cortex, cerebellum, dorsal root ganglion, spinal cord and testis. High expression in trigeminal ganglion, also expressed in autonomic nervous system ganglia such as the stellate ganglion and paravertebral sympathetic ganglia. Expressed in all adult spinal cord and brain regions, with slightly higher expression in thalamus, hypothalamus, hippocampus and posterior corte (at protein level). In non-neuronal tissues, substantial expression found in lung and heart and weal expression in liver, testis, kidney, small intestine and spleen.

Diseases

Migraine Disorders
Pain
Migraine With Aura
Has Tingling Sensation
Headache
Familial Hemiplegic Migraine
Nervousness
Headache Disorders
Pain Syndrome
Other Forms Of Migraine
Common Migraine

Paresthesia
Lymphoma
Dysequilibrium Syndrome
Nerve Damage
Channelopathies
Epilepsy

Pathways

Pathogenesis
Glycosylation
Localization
Ion Homeostasis

PTMs

Phosphorylation

Glycosylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Kcnk18

References

PMID: 14981085 by Czirjak G., et al. The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin.

PMID: 16192517 by Keshavaprasad B., et al. Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.