KDM1A Antibodies

AND KDM1A ELISA kits, KDM1A Proteins

Many biological assays use antibodies to detect KDM1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM1A antibodies...

We validate the specificity of these antibodies to KDM1A by testing them on tissues known to express KDM1A positively and negatively. Browse below to find the KDM1A antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KDM1A Infographic by Boster Bio

All KDM1A Products

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Product

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Specificity

Applications

Price

Anti-LSD1/AOF2 KDM1A Antibody (Monoclonal, 1B2F2)

Human, Mouse, Rat

$536
Cat # M00532
100μg/vial

Anti-KDM1/LSD1 KDM1A Rabbit Monoclonal Antibody

3 Q&As

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$370
Cat # M00532-1
100 μl

KDM1A Overview

Facts about Lysine-specific histone demethylase 1A.

KDM1A 3D structure. Source: alphafold

Lysine-specific histone demethylase 1A (KDM1A)

Histone demethylase that demethylates both'Lys-4' (H3K4me) and'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending upon the context. Followed by oxidizing the substrate by FAD to create the corresponding imine that's subsequently hydrolyzed.

Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. May play a role in the repression of neuronal genes.

Gene Information

Human
Gene Name:	KDM1A
Uniprot:	O60341
Entrez:	23028

Family

Belongs to:

flavin monoamine oxidase family

Alternative Names

amine oxidase (flavin containing) domain 2; AOF2; AOF2lysine-specific histone demethylase 1; BHC110; BHC110FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; KIAA0601KDM1; LSD1; LSD1BRAF35-HDAC complex protein BHC110; lysine (K)-specific demethylase 1; Lysine (K)specific Demethylase 1A; Lysine (K)-specific Demethylase 1A; lysine-specific histone demethylase 1A

Molecular Weight

Mass (kDA):
92.903 kDA

Genomic Context


Human

Location:	1p36.12
Sequence:	1; NC_000001.11 (23019443..23083691)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Leukemia
Prostatic Neoplasms
Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Leukemia, Myelocytic, Acute
Cell Transformation, Neoplastic
Adenocarcinoma
Cell Invasion
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Lung

Malignant Neoplasm Of Prostate
Retinoblastoma
Neoplasm Metastasis
Carcinogenesis
Colorectal Cancer
Hyperplasia
Neoplasm Invasiveness

Pathways

Methylation
Demethylation
Histone Methylation
Histone Demethylation
Cell Proliferation
Cell Cycle
Histone Modification
Chromatin Remodeling
Regulation Of Gene Expression
Histone Acetylation
Dna Methylation
Gene Silencing
Chromatin Modification

Chromosome Segregation
Cell Growth
Histone Lysine Methylation
Pathogenesis
Cell Cycle Arrest
Localization
Cell Death

PTMs

Methylation
Demethylation
Acetylation
Phosphorylation
Deacetylation

Oxidation
Sumoylation
Biotinylation
Reduction
Cleavage

Ubiquitination

Research Areas

DNA Repair
DNA replication, Transcription, Translation and Splicing
Epigenetics

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM1A

References

PMID: 12032298 by Hakimi M.-A., et al. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.

PMID: 11102443 by Humphrey G.W., et al. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.