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IFIH1 Antibodies
AND IFIH1 ELISA kits, IFIH1 Proteins
Many biological assays use antibodies to detect IFIH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFIH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFIH1 antibodies...
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IFIH1 Infographic by Boster Bio
All IFIH1 Products
Product
Figures
Specificity
Applications
Price
Human
$250
Cat # PROTQ9BYX4
2ug, 10ug, 1mg
Cat # PROTQ9BYX4
2ug, 10ug, 1mg
IFIH1 Overview
Facts about Interferon-induced helicase C domain-containing protein 1.
Interferon-induced helicase C domain-containing protein 1 (IFIH1)
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids also plays a significant role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O- methylation in their 5' cap and long-dsRNA (>1 kb in length).
Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE that phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, such as interferons (IFNs); IFN-alpha and IFN-beta. Responsible for discovering the Picornaviridae family members like encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG).
Gene Information
| Human | |
|---|---|
| Gene Name: | IFIH1 |
| Uniprot: | Q9BYX4 |
| Entrez: | 64135 |
Family
| Belongs to: |
|---|
| helicase family |
Alternative Names
CADM-140 autoantigen; Clinically amyopathic dermatomyositis autoantigen 140 kDa; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; EC 3.6.4.13; helicard; Helicase with 2 CARD domains; Hlcd; IDDM19; interferon induced with helicase C domain 1; interferon-induced helicase C domain-containing protein 1; Interferon-induced with helicase C domain protein 1; MDA-5MGC133047; MDA5RNA helicase-DEAD box protein 116; melanoma differentiation associated protein-5; Melanoma differentiation-associated protein 5; Murabutide down-regulated protein; RH116
Molecular Weight
Mass (kDA):
116.689 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q24.2 |
| Sequence: | 2; NC_000002.12 (162267074..162318684, complement) |
Tissue Specificity
Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung.
Subcellular Localizations
Cytoplasm. Nucleus. May be found in the nucleus, during apoptosis.
Diseases
- Melanoma
- Virus Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Insulin-dependent
- Infective Disorder
- Innate Immune Response
- Autoimmune Reaction
- Autoimmune Diseases
- Inflammation
- Autoimmunity
- Rna Virus Infections
- Lung Diseases
- Dermatomyositis
Interacting Proteins
- IKBKE
- MAVS
- RIOK3
- RNF125
- TKFC
Pathways
- Immune Response
- Pathogenesis
- Innate Immune Response
- Secretion
- Cell Death
- Type I Interferon Production
- Viral Replication
- Localization
- Cytokine Production
- Programmed Cell Death
- Inflammatory Response
- Cell Activation
- Tropism
PTMs
- Phosphorylation
- Cleavage
- Methylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFIH1
bosterbio.com/bosterbio-gene-info-cards/IFIH1
References
PMID: 11805321 by Kang D.-C., et al. mda-5: an interferon-inducible putative RNA helicase with double- stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.
PMID: 14645903 by Cocude C., et al. A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication.