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Hif3a Antibodies
AND Hif3a ELISA kits, Hif3a Proteins
Many biological assays use antibodies to detect Hif3a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hif3a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hif3a antibodies...
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Hif3a Infographic by Boster Bio
All Hif3a Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03805-3
100 μg/vial
Cat # A03805-3
100 μg/vial
Human
IHC, WB
$523
Cat # M03805
100 µl
Cat # M03805
100 µl
Hif3a Overview
Facts about Hypoxia-inducible factor 3-alpha.
Hypoxia-inducible factor 3-alpha (Hif3a)
Acts as a transcriptional regulator in adaptive response to low oxygen pressure. Acts as a regulator of hypoxia-inducible gene expression (PubMed:9840812, PubMed:11734856, PubMed:21546903).
Plays a role in the progression of the cardiorespiratory system (PubMed:18070924). .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Hif3a |
| Uniprot: | Q0VBL6 |
| Entrez: | 53417 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Basic-helix-loop-helix-PAS protein MOP7; BHLHE17; bHLHe17HIF-3A2; Class E basic helix-loop-helix protein 17; HIF-3A4; HIF-3-alpha; HIF3-alpha; hypoxia inducible factor 3, alpha subunit; hypoxia-inducible factor 3-alpha; hypoxia-inducible factor-3 alpha 4; Inhibitory PAS domain protein; IPASHIF3-alpha-1; Member of PAS protein 7; MOP7PAS domain-containing protein 7; PASD7HIF-3A
Molecular Weight
Mass (kDA):
73.044 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 7|7 A2 |
| Sequence: | 7; |
Tissue Specificity
Isoform 3 is expressed in endothelial cells of vessels and capillaries in alveoli of the neonatal lung (at protein level) (PubMed:18070924). Expressed in lung, brain, heart and kidney (PubMed:9840812). Isoform 2 is expressed in heart and lung (PubMed:12119283). Isoform 2 is highly expressed in the epithelial cell layer of the cornea with lower expression in the layers of ganglion cells, inner nuclear cells, and rods and cones of the retina (PubMed:11734856). Isoform 2 is expressed in the cerebellum only in the Purkinje cell layer (PubMed:11734856).
Diseases
- Hypoxia
- Anoxia
- Tumor Angiogenesis
- Neoplasms
- Malignant Neoplasms
- Von Hippel-lindau Syndrome
- Renal Cell Carcinoma
- Pulmonary Hypertension
- Hypertensive Disease
- Kidney Neoplasm
- Carcinoma
- Ischemia
- Hypertrophy
Pathways
- Angiogenesis
- Response To Hypoxia
- Oxygen Homeostasis
- Negative Regulation Of Angiogenesis
- Localization
- Regulation Of Angiogenesis
- Pathogenesis
- Transport
- Lung Development
- Cell Death
- Cell Growth
- Cell Adhesion
- Cell Migration
PTMs
- Hydroxylation
Research Areas
- Angiogenesis
- Cancer
- Hypoxia
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Hif3a
bosterbio.com/bosterbio-gene-info-cards/Hif3a
References
PMID: 9840812 by Gu Y.Z., et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.
PMID: 11734856 by Makino Y., et al. Inhibitory PAS domain protein is a negative regulator of hypoxia- inducible gene expression.