Serine protease HTRA1 Antibodies

AND HTRA1 ELISA kits, Serine protease HTRA1 Proteins

Many biological assays use antibodies to detect Serine protease HTRA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serine protease HTRA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serine protease HTRA1 antibodies...

We validate the specificity of these antibodies to Serine protease HTRA1 by testing them on tissues known to express HTRA1 positively and negatively. Browse below to find the HTRA1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HTRA1 Infographic by Boster Bio

All HTRA1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-HTRA1 Antibody Picoband®

5 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # A01801-1
100 μg/vial

HTRA1 (NM_002775) Human Over-expression Lysate

Human

$960
Cat # LS005654
100 µg

Anti-htrA1 Rabbit Monoclonal Antibody

Human

IF, ICC, WB

$370
Cat # M01801
100 µl/vial

HTRA1 Overview

Facts about Serine protease HTRA1.

HTRA1 3D structure. Source: alphafold

Serine protease HTRA1 (HTRA1)

Serine protease with many different targets, including extracellular matrix proteins like fibronectin. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin.

During cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the intensity and range of FGF signals in the extracellular space. Regulates the access to insulin-like growth factors (IGFs) by cleaving IGF-binding proteins.

Gene Information

Human
Gene Name:	HTRA1
Uniprot:	Q92743
Entrez:	5654

Family

Belongs to:

peptidase S1C family

Alternative Names

ARMD7; EC 3.4.21; EC 3.4.21.108; High-temperature requirement A serine peptidase 1; HtrA serine peptidase 1; HTRA1; IGFBP5-protease; L56; ORF480; PRSS11; Serine protease 11; serine, 11 (IGF binding)

Molecular Weight

Mass (kDA):
51.287 kDA

Genomic Context


Human

Location:	10q26.13
Sequence:	10; NC_000010.11 (122461553..122514907)

Tissue Specificity

Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).

Subcellular Localizations

Cell membrane. Secreted. Cytoplasm, cytosol. Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635).

Diseases

Age Related Macular Degeneration
Exudative Age-related Macular Degeneration
Blind Vision
Choroidal Neovascularization
Neoplasms
Maculopathy
Pathologic Neovascularization
Malignant Neoplasms
Atrophy
Geographic Atrophy
Dysequilibrium Syndrome
Disorder Of Eye

Arteriopathic Disease
Leukoencephalopathies
Abnormal Degeneration
Macule
Degenerative Polyarthritis
Visual Impairment

Interacting Proteins

THBS1

Pathways

Pathogenesis
Localization
Cell Growth
Proteolysis
Cell Death
Cell Proliferation
Angiogenesis
Complement Activation
Cell Migration
Eye Development
Regulation Of Angiogenesis
Immune Response
Oxidative Phosphorylation

Cell Cycle
Trophoblast Cell Migration
Gastrulation
Anoikis
Secretion
Cell Adhesion
Osteoblast Differentiation

PTMs

Cleavage

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTRA1

References

PMID: 8977104 by Zumbrunn J., et al. Primary structure of a putative serine protease specific for IGF- binding proteins.

PMID: 9852107 by Hu S.I., et al. Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage.