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- Table of Contents
Facts about Hematopoietic SH2 domain-containing protein.
Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. .
Human | |
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Gene Name: | HSH2D |
Uniprot: | Q96JZ2 |
Entrez: | 84941 |
Belongs to: |
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No superfamily |
Adaptor in lymphocytes of unknown function X; ALXHematopoietic SH2 protein; FLJ14886; hematopoietic SH2 domain containing; hematopoietic SH2 domain-containing protein; HSH2
Mass (kDA):
39.002 kDA
Human | |
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Location: | 19p13.11 |
Sequence: | 19; NC_000019.10 (16134028..16158575) |
Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta.
Cytoplasm. Nucleus.
PMID: 11700021 by Oda T., et al. HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells.
PMID: 12960172 by Greene T.A., et al. Cloning and characterization of ALX, an adaptor downstream of CD28.