HS3ST5 Antibodies

AND HS3ST5 ELISA kits, HS3ST5 Proteins

Many biological assays use antibodies to detect HS3ST5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HS3ST5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HS3ST5 antibodies...

We validate the specificity of these antibodies to HS3ST5 by testing them on tissues known to express HS3ST5 positively and negatively. Browse below to find the HS3ST5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: GPRC6A

HS3ST5 Infographic by Boster Bio

All HS3ST5 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

HS3ST5 (NM_153612) Human Over-expression Lysate

Human

$628
Cat # LS222537
100 µg

HS3ST5 Overview

Facts about Heparan sulfate glucosamine 3-O-sulfotransferase 5.

HS3ST5 3D structure. Source: alphafold

Heparan sulfate glucosamine 3-O-sulfotransferase 5 (HS3ST5)

Sulfotransferase that uses 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to place 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact).

This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2.

Gene Information

Human
Gene Name:	HS3ST5
Uniprot:	Q8IZT8
Entrez:	222537

Family

Belongs to:

sulfotransferase 1 family

Alternative Names

3-OST-5EC 2.8.2.23; 3OST5NBLA04021; EC 2.8.2; h3-OST-5; heparan sulfate (glucosamine) 3-O-sulfotransferase 5; heparan sulfate 3-OST-5; Heparan sulfate 3-O-sulfotransferase 5; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5; heparan sulfate glucosamine 3-O-sulfotransferase 5; HS3OST5

Molecular Weight

Mass (kDA):
40.408 kDA

Genomic Context


Human

Location:	6q21-q22.1
Sequence:	6; NC_000006.12 (114055586..114342395, complement)

Tissue Specificity

Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Growth Retardation
Congenital Anomaly Of Brain
Hypoplasia
Ataxia
Atrophy
Movement Disorders

Developmental Disabilities

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HS3ST5

References

PMID: 12138164 by Xia G., et al. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1.

PMID: 12740361 by Mochizuki H., et al. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide.