Histone H2A type 1-D (H2AC7)

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, restricting DNA accessibility to the cellular machineries which require DNA as a template.

Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated by means of a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.