Histone H2A-Bbd type 1 Antibodies

AND H2AB1 ELISA kits, Histone H2A-Bbd type 1 Proteins

Many biological assays use antibodies to detect Histone H2A-Bbd type 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Histone H2A-Bbd type 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Histone H2A-Bbd type 1 antibodies...

We validate the specificity of these antibodies to Histone H2A-Bbd type 1 by testing them on tissues known to express H2AB1 positively and negatively. Browse below to find the H2AB1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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H2AB1 Infographic by Boster Bio

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Histone H2A Bbd (H2AFB1) (NM_001017990) Human Over-expression Lysate

Human

$628
Cat # LS474382
100 µg

H2AB1 Overview

Facts about Histone H2A-Bbd type 1.

H2AB1 3D structure. Source: alphafold

Histone H2A-Bbd type 1 (H2AB1)

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, restricting DNA accessibility to the cellular machineries which require DNA as a template.

Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483).

Gene Information

Human
Gene Name:	H2AB1
Uniprot:	P0C5Y9
Entrez:	474382

Family

Belongs to:

histone H2A family

Alternative Names

Histone H2A-Bbd type 1

Molecular Weight

Mass (kDA):
12.697 kDA

Genomic Context


Human

Location:	Xq28
Sequence:	X; NC_000023.11 (154884972..154885558)

Tissue Specificity

Present in mature sperm.

Subcellular Localizations

Nucleus. Chromosome. Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/H2AB1

References

PMID: 8528212 by Naylor J.A., et al. Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions.

PMID: 15257289 by Bao Y., et al. Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA.