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- Table of Contents
Facts about Guanine nucleotide-binding protein G(i) subunit alpha.
Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the sign.
Human | |
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Gene Name: | GNAI3 |
Uniprot: | P08754 |
Entrez: | 2773 |
Belongs to: |
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G-alpha family |
FLJ26559; G(i) alpha-3; guanine nucleotide binding protein (G protein), alpha inhibiting activitypolypeptide 3,87U6; guanine nucleotide-binding protein G(k) subunit alpha
Mass (kDA):
40.532 kDA
Human | |
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Location: | 1p13.3 |
Sequence: | 1; NC_000001.11 (109548615..109600195) |
Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
PMID: 3109953 by Didsbury J.R., et al. Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families.
PMID: 3120178 by Beals C.R., et al. A small multigene family encodes Gi signal-transduction proteins.