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GLI3 Antibodies
AND GLI3 ELISA kits, GLI3 Proteins
Many biological assays use antibodies to detect GLI3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GLI3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GLI3 antibodies...
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GLI3 Infographic by Boster Bio
All GLI3 Products
Product
Figures
Specificity
Applications
Price
Anti-Transcriptional activator GLI3 Gli3 Antibody Picoband®
1 Citations 5 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1766
100 μg/vial
Cat # PA1766
100 μg/vial
GLI3 Overview
Facts about Transcriptional activator GLI3.
Transcriptional activator GLI3 (GLI3)
Has a double function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full size GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, functions as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor.
A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of this zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | GLI3 |
| Uniprot: | P10071 |
| Entrez: | 2737 |
Family
| Belongs to: |
|---|
| GLI C2H2-type zinc-finger protein family |
Alternative Names
ACLS; ACLSPAPAPHS; ADD; Bph; GCPS; GLI family zinc finger 3; GLI3 form of 190 kDa; GLI3 full length protein; GLI3; GLI-3; GLI3-190; GLI3FL; GLI-Kruppel family member GLI3; glioma-associated oncogene family zinc finger 3; Greig cephalopolysyndactyly syndrome; oncogene GLI3; PAP-A; PAPA1; PAPB; PAPBDNA-binding protein; Pdn; PHS; PPDIV; Xt; zinc finger protein GLI3
Molecular Weight
Mass (kDA):
169.863 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p14.1 |
| Sequence: | 7; NC_000007.14 (41960949..42237209, complement) |
Tissue Specificity
Is expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium.
Subcellular Localizations
Nucleus. Cytoplasm. Cell projection, cilium. GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Translocation to the nucleus is promoted by interaction with ZIC1.
Diseases
- Polydactyly
- Greig Cephalopolysyndactyly Syndrome
- Malignant Neoplasms
- Neoplasms
- Pallister-hall Syndrome
- Syndactyly
- Congenital Abnormality
- Hamartoma
- Craniofacial Abnormalities
- Haploinsufficiency
- Carcinoma
- Nervousness
Interacting Proteins
- Spop
- STK36
- SUFU
- Zic1
- Zic2
Pathways
- Limb Development
- Cell Proliferation
- Localization
- Pathogenesis
- Transport
- Cell Death
- Neurogenesis
- Intraflagellar Transport
- Cell Cycle
- Ossification
- Cell Differentiation
- Endochondral Ossification
- Osteoblast Differentiation
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLI3
bosterbio.com/bosterbio-gene-info-cards/GLI3
References
PMID: 2118997 by Ruppert J.M., et al. GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.
PMID: 10441342 by Kalff-Suske M., et al. Point mutations throughout the GLI3 gene cause Greig cephalopolysyndactylysyndrome.
1 Publications of Boster GLI3 Antibodies & ELISA Kits
- PubMed ID: 25288466, Kumari S, Chaurasia Sn, Kumar K, Dash D. Thromb Res. 2014 Dec;134(6):1311-5. Doi...
*More publications can be found for each product on its corresponding product page