RNA-binding protein FUS Antibodies

AND FUS ELISA kits, RNA-binding protein FUS Proteins

Many biological assays use antibodies to detect RNA-binding protein FUS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNA-binding protein FUS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNA-binding protein FUS antibodies...

We validate the specificity of these antibodies to RNA-binding protein FUS by testing them on tissues known to express FUS positively and negatively. Browse below to find the FUS antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FUS Infographic by Boster Bio

All FUS Products

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Product

Figures

Specificity

Applications

Price

Anti-TLS/FUS Antibody Picoband®

14 Q&As

Human, Mouse, Rat

$370
Cat # A00771-1
100 μg/vial

Anti-FUS / TLS Rabbit Monoclonal Antibody

16 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00771
100 μl

Anti-FUS/TLS Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$405
Cat # A00771-2
100ul

Anti-TLS/FUS Antibody Picoband®

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00771-3
100 μg/vial

FUS (NM_004960) Human Over-expression Lysate

Human

$628
Cat # LS002521
100 µg

FUS Overview

Facts about RNA-binding protein FUS.

FUS 3D structure. Source: alphafold

RNA-binding protein FUS (FUS)

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

Gene Information

Human
Gene Name:	FUS
Uniprot:	P35637
Entrez:	2521

Family

Belongs to:

RRM TET family

Alternative Names

75 kDa DNA-pairing protein; ALS6; amyotrophic lateral sclerosis 6; FUS1; fused in sarcoma; fusion (involved in t(12;16) in malignant liposarcoma); fusion gene in myxoid liposarcoma; fusion, derived from t(12;16) malignant liposarcoma; fus-like protein; heterogeneous nuclear ribonucleoprotein P2; HNRNPP2; Oncogene FUS; Oncogene TLS; POMP75; RNA-binding protein FUS; TLShnRNP-P2; Translocated in liposarcoma protein

Molecular Weight

Mass (kDA):
53.426 kDA

Genomic Context


Human

Location:	16p11.2
Sequence:	16; NC_000016.10 (31180110..31194871)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Displays a punctate pattern inside the nucleus and is excluded from nucleoli.

Diseases

Feline Urological Syndrome
Amyotrophic Lateral Sclerosis
Sclerosis
Primary Lateral Sclerosis
Neoplasms
Sarcoma
Liposarcoma
Neurodegenerative Disorders
Frontotemporal Lobar Degeneration
Chromosomal Translocation
Malignant Neoplasms
Dementia
Nerve Degeneration

Liposarcoma, Myxoid
Frontotemporal Dementia
Soft Tissue Neoplasms
Malignant Paraganglionic Neoplasm
Leukemia
Neoplasm Metastasis
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)

Interacting Proteins

Crebbp
DROSHA
EP300
EWSR1
KAT5

PLEC
PRMT1
RBMX
SAFB
TAF15

TP63

Pathways

Pathogenesis
Localization
Translation
Transport
Rna Processing
Mrna Processing
Cell Death
Oncogenesis
Coagulation
Cell Proliferation
Methylation
Photomorphogenesis
Rna Splicing

Seedling Development
Mrna Transport
Nuclear Import
Conjugation
Cognition
Muscle Atrophy
Interphase

PTMs

Phosphorylation
Ubiquitination
Cleavage
Methylation

Ribosylation
Sumoylation
Demethylation
Glycosylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FUS

References

PMID: 8510758 by Crozat A., et al. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.

PMID: 7503811 by Rabbitts T.H., et al. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.