Fgd2 Antibodies

AND Fgd2 ELISA kits, Fgd2 Proteins

Many biological assays use antibodies to detect Fgd2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fgd2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fgd2 antibodies...

We validate the specificity of these antibodies to Fgd2 by testing them on tissues known to express Fgd2 positively and negatively. Browse below to find the Fgd2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Fgd2 Infographic by Boster Bio

All Fgd2 Products

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FGD2 (NM_173558) Human Over-expression Lysate

Human

$628
Cat # LS221472
100 µg

Fgd2 Overview

Facts about FYVE, RhoGEF and PH domain-containing protein 2.

FYVE, RhoGEF and PH domain-containing protein 2 (Fgd2)

Activates CDC42, a Part of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.
Activates JNK1 through CDC42 but not RAC1.

Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. .

Gene Information

Mouse
Gene Name:	Fgd2
Uniprot:	Q8BY35
Entrez:	26382

Family

Belongs to:

No superfamily

Alternative Names

FGD1 family, member 2; FLJ00048; FLJ00276 protein; FLJ40929; FYVE, RhoGEF and PH domain containing 2; FYVE, RhoGEF and PH domain-containing protein 2; ZFYVE4MGC71330; Zinc finger FYVE domain-containing protein 4

Molecular Weight

Mass (kDA):
74.634 kDA

Genomic Context


Mouse

Location:	17 15.26 cM\|17 A3.3
Sequence:	17;

Tissue Specificity

Lymph node, spleen, B-lymphocytes and macrophages (at protein level). Expressed at high levels in lymph node, spleen, B-lymphocytes and bone marrow macrophages. Expressed at lower levels in mature bone marrow dendritic cells. In both immature and mature B-cells, expression is down-regulated by prior B-cell receptor signaling. Expression remains high in resting B and memory cells but declines upon differentiation into plasma cells.

Diseases

Dysplasia
Developmental Disabilities
Urogenital Abnormalities
Chronic Inflammation
Inflammatory Bowel Diseases
Adrenal Cortex Diseases
Intestinal Diseases
Ulcerative Colitis
Ulcer

Crohn Disease
Inflammation
Colitis

Pathways

Sperm Motility
Cell Growth
Pathogenesis
Localization

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Fgd2

References

PMID: 10458911 by Pasteris N.G., et al. Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues.