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- Table of Contents
Facts about Protein FAM83A.
Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, in addition, it activates both signaling cascades independently of EGFR activation. .
Human | |
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Gene Name: | FAM83A |
Uniprot: | Q86UY5 |
Entrez: | 84985 |
Belongs to: |
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FAM83 family |
Protein FAM83A
Mass (kDA):
47.458 kDA
Human | |
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Location: | 8q24.13 |
Sequence: | 8; NC_000008.11 (123179047..123210079) |
Cytoplasm.
PMID: 22886303 by Lee S.Y., et al. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice.
PMID: 24736947 by Cipriano R., et al. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer.