RNA polymerase II elongation factor ELL (ELL)

Elongation factor part of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor part of the tiny elongation complex (LEC), a complex necessary to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780).

Especially required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also has an early role before its assembly into from the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site.