DXO Antibodies

AND DXO ELISA kits, DXO Proteins

Many biological assays use antibodies to detect DXO, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DXO in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DXO antibodies...

We validate the specificity of these antibodies to DXO by testing them on tissues known to express DXO positively and negatively. Browse below to find the DXO antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DXO Infographic by Boster Bio

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DOM3Z (DXO) (NM_005510) Human Over-expression Lysate

Human

$628
Cat # LS001797
100 µg

DXO Overview

Facts about Decapping and exoribonuclease protein.

DXO 3D structure. Source: alphafold

Decapping and exoribonuclease protein (DXO)

Ribonuclease that specifically degrades pre-mRNAs with a faulty 5' end cap and is a part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities.

Has decapping activity toward immaculate 5' end cap mRNAs like unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and hamper incompletely capped mRNAs.

Gene Information

Human
Gene Name:	DXO
Uniprot:	O77932
Entrez:	1797

Family

Belongs to:

DXO/Dom3Z family

Alternative Names

DOM-3 (C. elegans) homolog Z; dom-3 homolog Z (C. elegans); Dom-3 homolog Z; DOM3L; DOM3Z; NG6; protein Dom3Z; RAI1

Molecular Weight

Mass (kDA):
44.929 kDA

Genomic Context


Human

Location:	6p21.33
Sequence:	6; NC_000006.12 (31969811..31972290, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus.

Diseases

Mutation, Out-of-frame
Autoimmune Reaction
Lupus Erythematosus, Systemic
Autoimmune Diseases

Pathways

Translation
Regulation Of Translation
Mrna Processing
Regulation Of Gene Expression
Rna Interference
Localization
Rna Splicing

Secretion

PTMs

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DXO

References

PMID: 9799600 by Yang Z., et al. Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z- RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA.

PMID: 10686478 by Yang Z., et al. Organizations and gene duplications of the human and mouse MHC complement gene clusters.