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- Table of Contents
Facts about Beta-defensin 103.
Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.
pyogenes, Gram-negative bacteria P.aeruginosa and E.
Human | |
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Gene Name: | DEFB103A |
Uniprot: | P81534 |
Entrez: | 414325 |
Belongs to: |
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beta-defensin family |
Beta-defensin 103
Mass (kDA):
7.697 kDA
Human | |
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Location: | 8p23.1 |
Sequence: | 8; NC_000008.11 (7881392..7882663) |
Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.
Secreted.
PMID: 11085990 by Harder J., et al. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic.
PMID: 11702237 by Conejo-Garcia J.-R., et al. Identification of a novel, multifunctional beta-defensin (human beta- defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction.