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- Table of Contents
Facts about DDB1- and CUL4-associated factor 1.
Involved in the turnover of methylated proteins: recognizes and binds methylated proteins through its chromo domain, leading to ubiquitination of target proteins from the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination.
Human | |
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Gene Name: | DCAF1 |
Uniprot: | Q9Y4B6 |
Entrez: | 9730 |
Belongs to: |
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VPRBP/DCAF1 family |
DDB1- and CUL4-associated factor 1
Mass (kDA):
169.007 kDA
Human | |
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Location: | 3p21.2 |
Sequence: | 3; NC_000003.12 (51394261..51505620, complement) |
Ubiquitously expressed.
Cytoplasm. Nucleus. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis.
PMID: 11223251 by Zhang S., et al. Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein- protein interaction with a novel human cytoplasmic protein VprBP.
PMID: 8195203 by Zhao L.-J., et al. Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.